KSBNS 2023
The 26th Annual Meeting of the Korean Society for Brain and Neural Sciences
September 6(Wed)-8(Fri), 2023
BEXCO, Busan, South Korea
September 6(Wed)-8(Fri), 2023
BEXCO, Busan, South Korea
Eunji Cheong (Yonsei University)
ModeratorEunji Cheong (Yonsei University)
Sensory processing is an initial step to connect cognitive function to the external world. In this symposium, the speakers would cover sensory processing in a wide range of brain circuits, including the midbrain, thalamus, and primary sensory cortex, with diverse approaches and provide an insight into how sensory information is decoded and integrated in the brain.
| Speaker | Affiliation | Title |
|---|---|---|
| Garrett B. Stanley | Georgia Institute of Technology | Windows of opportunity in the thalamocortical circuit 2.0: a canonical computation? |
| Jeehyun Kwag | Seoul National University | Distinct roles of GABAergic interneurons in neural coding of texture in the barrel cortex |
| Gunsoo Kim | Korean Brain Research Institute | Integration of sound and movement in the mouse auditory midbrain |
| Eunji Cheong | Yonsei University | Neural and glial modulation of thalamocortical neurons |
Jinhyun Kim (Korea Institute of Science and Technology)
Changhyuk Lee (Korea Institute of Science and Technology)
Keiko Tanaka-Yamamoto (Korea Institute of Science and Technology)
ModeratorJinhyun Kim (Korea Institute of Science and Technology)
Changhyuk Lee (Korea Institute of Science and Technology)
Co-organized by Korea Institute of Science & Technology
The way and skill of social interactions are developed very early and affected by social circumstances. With the advent of digital technology and the recent worldwide frightening COVID-19 pandemic, our social interactions are dramatically changed. In fact, the effects on children’s social development by the pandemic, as well as the digital lifestyle, are increasingly spotlighted by society. In this critical era, the KIST BSI symposium aims to bring attention to research on mechanisms of social interactions, analyses of risk factors by comprehensive algorisms, and advanced clinical tools, with particular attention to neurodevelopmental disorders such as autism spectrum disorder (ASD).
| Speaker | Affiliation | Title |
|---|---|---|
| Bung-Nyun Kim | Seoul National University Hospital | New system and new hope for Autism Spectrum Disorder: early diagnosis and treatment in Korea |
| Frederick Shic | University of Washington | Social attention in autism: developmental processes viewed through an eye-tracking lens |
| Robert C. Froemke | New York University | Love, death, and oxytocin: the challenges of mouse maternal care |
| Ann Clemens | University of Edinburgh | Neural circuits of kinship behaviour |
Hyoung F. Kim (Seoul National University)
ModeratorHyoung F. Kim (Seoul National University)
The theme of this symposium is how the primate and rodent brains process the high cognitive functions, such as reasoning, cognitive state-selective behavior, learning, and reporting illusions. These "high levels of cognitive function" are critical for better survival, and understanding their biological mechanisms will provide insight into neuropsychiatry disorders. This symposium will be a forum for intensive discussion on future research on high cognitive functions using rodent and non-human primate brains.
| Speaker | Affiliation | Title |
|---|---|---|
| Seng Bum Michael Yoo | Sungkyunkwan University | Cognitive state selective behavior and neural signature in nonhuman primates during the navigation at virtual reality |
| Hansem Sohn | Sungkyunkwan University | Dynamic tracking of objects in the macaque dorsomedial frontal cortex |
| Jaewon Hwang | National Institute of Health | Distinctive roles of amygdala and orbitofrontal cortex in autonomic regulation during associative learning in macaques |
| Hyeyoung Shin | Seoul National University | Recurrent pattern completion drives the neocortical representation of sensory inference |
C. Justin Lee (Institute for Basic Science)
Mijin Yun (Yonsei University)
ModeratorC. Justin Lee (Institute for Basic Science)
Reactive astrogliosis is a common clinical phenomenon observed in various pathological conditions associated with neuroinflammation in the brain. Recent studies have elucidated the common molecular and metabolic alterations of reactive astrocytes, as well as their contributions to the pathologies of Alzheimer’s disease (AD) and glioblastoma. These studies have also enabled the development of strategies for the functional PET/CT imaging of reactive astrogliosis. In this symposium, we will present recent novel findings on how reactive astrocytes contribute to the pathologies of AD and glioblastoma, as well as how we can image the reactive astrocytes in patients with AD and glioblastoma.
| Speaker | Affiliation | Title |
|---|---|---|
| Yeon Ha Ju | The University of Texas at Austin | Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer’s disease |
| Min-Ho Nam | Korea Institute of Science and Technology | PET imaging reveals reactive astrocyte-mediated neuronal hypometabolism in Alzheimer’s disease patients |
| Mijin Yun | Yonsei University | PET imaging of reactive astrogliosis extends patient survival in glioblastoma |
| Hansang Cho | Sungkyunkwan University | Astrocytic scar restricting glioblastoma via glutamateglioblastoma-microglia assembled |
Joung Hun Kim (Pohang University of Science and Technology)
ModeratorJoung Hun Kim (Pohang University of Science and Technology)
Neural cells and their intricate networks are responsible for all our perceptions, thoughts and memories. Understanding how cellular and synaptic mechanisms within neural circuits produce behavioral changes particularly involved in addictive behaviors and motivation, is a fundamental goal of neuroscience and science also. To achieve this goal, we need a number of new tools and concepts to capture causal components of behavioral changes and comprehend the neural mechanisms. Presently we witness enormous expansion of our knowledges for cellular and molecular mechanisms whereby addiction memory and motivation could be shaped and adjusted. At this symposium, leading researchers studying neural circuits and their mechanisms for behavioral changes will present exciting new results and prompt better understanding for how neural circuits dictate addiction memory and motivation.
| Speaker | Affiliation | Title |
|---|---|---|
| Yan Dong | University of Pittsburgh | Neurocircuit remodeling in motivated behavior |
| Jung Ho Hyun | Daegu Gyeongbuk Institute of Science and Technology | Neurocomputational underpinnings of structural knowledge-based flexible decision-making |
| Ja-hyun Baik | Korea University | Dopamine- Insulin signaling crosstalk in the central nucleus of the amygdala balances compulsive eating behavior |
| Juhyun Kim | Korean Brain Research Institute | Layer 6b cortical circuit in social memory and behaviors |
Jae-Ick Kim (Ulsan National Institute of Science and Technology)
ModeratorJae-Ick Kim (Ulsan National Institute of Science and Technology)
Dopaminergic transmission and dopamine receptor-mediated signaling pathways govern diverse cognitive and psychomotor functions. Although the number of dopamine-synthesizing neurons in the midbrain is very small, they project to wide areas of the brain via huge axonal arborization and synapses, exerting a strong influence throughout the brain. Despite this significance, the true nature of dopaminergic transmission and dopamine-mediated neuronal function remains poorly understood. However, recent technological advances and new findings about the dopamine system are enabling us to ask more detailed questions about how the dopamine system in the brain works in health and disease. In this symposium, the speakers will cover the following topics in current dopamine system research: neurotechnology for long-term neurotransmitter monitoring in the brain, optogenetic approaches to investigate the spatiotemporal function of dopamine receptors, decoding neuromodulations in the brain, and distinct modes of dopaminergic modulation on striatopallidal synaptic transmission in health and Parkinsonism.
| Speaker | Affiliation | Title |
|---|---|---|
| Dong-Pyo Jang | Hanyang University | Neurotechnology for long-term tonic dopamine monitoring in the brain |
| Jihye Seong | Korea Institute of Science and Technology | Optical sensing and control of dopamine transmission for the study of brain function and disease |
| Jun Ding | Stanford University | Bi-directional regulation of synaptic plasticity by dopamine and dynorphin |
| Jae-Ick Kim | Ulsan National Institute of Science and Technology | Distinct modes of dopaminergic modulation on striatopallidal transmission in health and Parkinsonism |
Chun Kee Chung (Seoul National University)
ModeratorChun Kee Chung (Seoul National University)
Brain-computer interface (BCI) is a useful tool to interpret the brain. With a brain modulation technique, it can be expanded to enhance the brain function and to generate virtual perception or cognition. Although there have been successful achievements for movement BCI of robot arm and wheel-chair controls, cognitive BCI such as language is still challenging. The purpose of this symposium is to share recent advancement of the brain decoding and encoding researches for brain-computer interface. The symposium focuses on the speech function such as hearing and verbal production in both of human and animals. It includes encoding strategy using electrical brain stimulation as well as the recent decoding techniques for invasive electrodes.
| Speaker | Affiliation | Title |
|---|---|---|
| Chun Kee Chung | Seoul National University | Induction of speech perception through direct electrical brain stimulation in humans |
| Sung-Phil Kim | Ulsan National Institute of Science and Technology | Modeling and decoding sound information with auditory cortical activity |
| Chang-Hee Han | Korea University | Speech synthesis from neural signals using deep neural networks |
| Sungchil Yang | City University of Hong Kong | Graphene array-based decoding/encoding of auditory perception in rodents |
Sung Joong Lee (Seoul National University)
ModeratorSung Joong Lee (Seoul National University)
Traditionally glial cells were regarded as merely a supporting cells for neurons. However, recent studies discovered that glial cells are actively involved in synaptic transmission via tripartite synapse. Thereby, glial cells can regulate information processing in physiological brain function and even behaviors. In this symposium, speakers will present and discuss recent discoveries on the role of glial cells in physiological high-oder brain functions such as learning/memory, sensory perception, and affective brain functions.
| Speaker | Affiliation | Title |
|---|---|---|
| Inbal Goshen | Hebrew University | Astrocytes in higher brain function |
| Sung Joong Lee | Seoul National University | Astrocytes regulate mouse affective and dominance behaviors |
| C. Justin Lee | Institute for Basic Science | Role of astrocytic d-serine and glutamate in formation of flexible memory |
| Sang Jeong Kim | Seoul National University | Astrocyte-mediated pain modulation in cerebellum |
Sung-Jin Jeong (Korea Brain Research Institute)
Sang Ho Yoo (Hanyang University)
ModeratorSung-Jin Jeong (Korea Brain Research Institute)
Sang Ho Yoo (Hanyang University)
As the progress of neural organoid research accelerated, publications using various terms such as cerebral organoids, brain organoids, etc, came out one after another. A recent article pointed out that the lack of a clear consensus makes it challenging for researchers and the public to follow and to clearly delineate technological advances and needs. Moreover, in recent study, human stem cell-derived cortical organoid has been transplanted into the cortex of newborn rat enabling to produce the sensory response against the input. In this session, we discuss the innovative technology of neural organoids and the ethical concerns to create the practical considerations for researchers and the public.
| Speaker | Affiliation | Title |
|---|---|---|
| Woong Sun | Korea University | Exploring pain sensation in human spinal cord organoids: Implications for ethical considerations in organoid research |
| Haruhisa Inoue | Kyoto University | Stem cell technology for basic and clinical neuroscience |
| Tsung-Ling Lee | Taipei Medical University | Brain organoids: transnational legal issues |
| Sang-Ho Yoo | Hanyang University | Ethical, legal, and social implications of brain organoids technology : A study on awareness among professional researchers in Korea |
Maesoon Im (Korea Institute of Science and Technology)
ModeratorIn-Beom Kim (The Catholic University of Korea)
Our vision is originated from the retina, which performs incredibly complex neural computations before sending visual neural signals to the downstream visual centers. In the proposed symposium, three retinal neurophysiology experts will present their recent researches about how ion channels (e.g., Na channels, HCN channels, ANO1 and IK channels) and receptors (e.g., acetylcholine receptors) expressed in the retinal neurons contribute to the complicated neural computations and how retinal degeneration alters those neural components. This symposium will offer the most recent updates as well as some insights regarding the working principles of the retina, which is the earliest stage of the visual system. Those updates and insights are highly likely to be applicable to the other parts of the central nervous system.
| Speaker | Affiliation | Title |
|---|---|---|
| Tomomi Ichinose | Wayne State University | How Na channels, HCN channels, and acetylcholine receptors of retinal bipolar cells contribute to visual signaling |
| Yong Soo Park | The Catholic University of Korea | Intermediate-conductance calcium-activated potassium channel regulates synaptic transmission from rod bipolar cell to AII amacrine cell |
| Maesoon Im | Korea Institute of Science and Technology | Changes of HCN channels in the retina as a function of retinal degeneration |
Sung-Phil Kim (Ulsan National Institute of Science and Technology)
ModeratorSung-Phil Kim (Ulsan National Institute of Science and Technology)
This symposium aims to provide an avenue to share and discuss recent advances in neural interfacing and signal processing technologies with pioneering researchers in related fields. The effort to merge neural interfaces and neural signal processing methods into a single place aims to enhance interactions between two closely-related neuroengineering fields, envisioning reciprocal benefits for both fields. Moreover, general neuroscientists can also find such integrated neural interfaces greatly useful to their researches to understand neural mechanisms. The symposium will also open discussion about how neural interfaces can help to foster neuroscience research and to improve neuroprosthetics.
| Speaker | Affiliation | Title |
|---|---|---|
| Vikash Gilja | University of California, San Diego | Towards neural activity driven vocalization prostheses |
| Sohee Kim | Daegu Gyeongbuk Institute of Science and Technology | Interfacing the nervous system with soft and flexible interfaces |
| Il-Joo Cho | Korea University | Neural probe system for wireless monitoring and modulation of neural activities |
| Hangue Park | Sungkyunkwan University | Neural rewiring and motor rehabilitation by integrated sensory neuro-prosthesis |
Seung-Hee Lee (Korea Advanced Institute of Science and Technology)
ModeratorSeung-Hee Lee (Korea Advanced Institute of Science and Technology)
Co-organized by Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS)
Recent advances in imaging, recording, and manipulation techniques applicable to behaving animals in vivo allowed researchers to dissect functional circuits for sensation and perception from the periphery to the brain. This symposium will introduce recent studies on neural circuit mechanisms for perceiving various sensory information in the mammalian brain. First, Professor Seungwon Choi at UT Southwestern will present his recent findings on the ascending somatosensory circuits that shape touch and pain perception. Next, Professor Dan Feldman at UC Berkeley will present his long-term work on microcircuits in the somatosensory cortex and explain how the cortical network processes sensory information in health and disease. The third speaker, Professor Marla Feller at UC Berkeley, renowned for her seminal work on the role of retinal waves on the development of the retina, will present her recent findings on the retina circuits. Finally, the last speaker, Professor Sung-Yon Kim at Seoul National University, will present his recent findings on thermoregulation, how the brain senses the temperature and transforms it into a motivational signal for adjusting their behaviors.
| Speaker | Affiliation | Title |
|---|---|---|
| Seungwon Choi | University of Texas Southwestern | Ascending somatosensory circuitry that shapes the sense of touch and pain |
| Dan Feldman | University of California, Berkeley | Flexible neural coding in whisker primary somatosensory cortex |
| Marla Feller | University of California, Berkeley | A role for spontaneous neural activity in development of retinal direction selectivity |
| Sung-Yon Kim | Seoul National University | How do we turn on the heat when it is cold? |
Alexa Woo (Case Western Reserve University)
ModeratorDavid Kang (Case Western Reserve University)
This symposium will cover the underlying mechanisms of neural injury underpinning the pathogenesis of Alzheimer’s disease and related dementias (ADRDs). It is well recognized that multiple factors drive neurodegenerative diseases, including genetics, epigenetics, and environment. It is therefore critical to understand the underlying mechanisms of neural injury, such as sex-biased vulnerability, traumatic brain injury (TBI), oxidative stress, nuclear signaling, and proteinopathy in ADRDs. The speakers in this session will cover broad aspects of neural injury mechanisms in ADRDs.
| Speaker | Affiliation | Title |
|---|---|---|
| David Kang | Case Western Reserve University | Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer’s disease |
| Andrew A. Pieper | Harrington Discovery Institute at University Hospitals | Reversal of chronic neurodegenerative disease with an NAD+/NADH stabilizing neuroprotective molecule |
| Bindu Paul | Johns Hopkins University | Neuroprotective roles of biliverdin reductase, a component of a metabolic traffic signal |
| Alexa Woo | Case Western Reserve University | X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women |
Sue-Hyun Lee (Seoul National University)
ModeratorSue-Hyun Lee (Seoul National University)
A sequence is the arranging of thought and behavior in a logical and sequential manner. Since the early 1950s, sequence processing has been studied in diverse cognitive domains, including language, music, mathematics, and memory. Due to the intricacy of its processing, sequence processing incorporates multiple executive functions, such as cognitive control, rule learning, and memory. This symposium addresses various viewpoints on sequence processing in human cognition, introducing its neural correlates from different perspectives of motor, language, memory, and statistical learning and discussing how sequence processing is interwoven with several cognitive functions.
| Speaker | Affiliation | Title |
|---|---|---|
| Sungshin Kim | Hanyang University | Neural representation of human motor control |
| Sung-Joo Lim | Binghamton University | Cognitive impact of featural discontinuity on speech processing |
| Sue-Hyun Lee | Seoul National University | Hippocampal processing during learning and retrieval for long-lasting long-term memory |
| Hyeon-Ae Jeon | Daegu Gyeongbuk Institute of Science and Technology | Reduced functional connectivity supports statistical learning of temporally distributed regularities |
Kihoon Han (Korea University)
Eunha Kim (Korea University)
ModeratorKihoon Han (Korea University)
Neurodevelopmental disorders, such as autism spectrum disorders, malformations of cortical development, and neural tube defects, are complex diseases caused by a combination of both genetic and environmental risk factors. In this symposium, we would like to present and discuss about the recently emerging and clinically relevant genetic (brain somatic mutations) and environmental (maternal inflammation, anesthesia, and antiepileptic drugs) risk factors and their neurobiological mechanisms on the pathogenesis of neurodevelopmental disorders. The results obtained by a wide range of model systems (mice, human tissues, and organoids) and cutting-edge technologies (single-cell multi-omics) will be presented by speakers from diverse backgrounds (e.g., both basic researchers and a clinician).
| Speaker | Affiliation | Title |
|---|---|---|
| Changuk Chung | University of California, San Diego | Brain somatic mutations in malformations of cortical development |
| Eunha Kim | Korea University | Long-lasting consequences of inflammation during pregnancy in rodent offspring |
| Woosuk Chung | Chungnam National University Hospital | General anesthesia during neurodevelopment, is it safe? |
| Ju-Hyun Lee | Korea Institute of Science and Technology | Modeling human neurodevelopmental disorders using spinal cord organoids |
Doyun Lee (Institute for Basic Science)
ModeratorDoyun Lee (Institute for Basic Science)
Recognizing one’s social counterpart is the most important process in many forms of social interaction. In this symposium, the authors will present recent findings on how different brain regions represent “others” during social interactions in healthy and autistic animals. The authors will also discuss how a lack of social interaction affects cognition and behavior and which brain regions are critically involved in the process.
| Speaker | Affiliation | Title |
|---|---|---|
| Doyun Lee | Institute for Basic Science | Dynamic and stable hippocampal representations of social identity and reward expectation support associative social memory in male mice |
| Teruhiro Okuyama | The University of Tokyo | Social memory representation in the hippocampal ventral CA1 neurons |
| Jeongyeon Kim | Korea Brain Research Institute | Serotonin receptor 4 in the lateral habenula modulates synaptic plasticity and social decision in socially isolated mice |
| Eunee Lee | Yonsei University | Autism and social deficit: Investigating how 'self' and 'others' are encoded in the autistic rodent brain |
Choong-Wan Woo (Sungkyunkwan University)
ModeratorChoong-Wan Woo (Sungkyunkwan University)
Our session will explore the relationship between the spontaneous fluctuations of brain activity and the generation of spontaneous thoughts and cognition. We will focus on the recent advances in neuroimaging (e.g., fMRI and EEG) and computational modeling methods to study spontaneous brain dynamics and their behavioral relevance (e.g., mind wandering), highlighting the importance of spontaneous brain activity in the understanding of higher-level cognition.
| Speaker | Affiliation | Title |
|---|---|---|
| John Murray | Yale University | Spectral states in human cortex undergo global shifts in bimodal dynamical regimes |
| Seok-Jun Hong | Sungkyunkwan University | Consensus mapping of effective connectivity revealed state-dependent asymmetric functional flows along the cortical hierarchy in the human brain |
| Choong-Wan Woo | Sungkyunkwan University | Brain decoding of spontaneous cognition |
| Joon-Young Moon | Institute for Basic Science | Human brain fluctuates between top-down and bottom-up modes of dynamics |
Hyung Jin Choi (Seoul National University)
ModeratorHyung Jin Choi (Seoul National University)
When homeostasis is threatened or disrupted, the body responds in order to restore balance. Stress can threaten homeostasis in multiple ways, from energy balance to social relationships, and it can have significant negative effects on physical and mental health if left unchecked. Social homeostasis refers to the balance of social interactions and relationships in the body, a disruption of social connections can also cause homeostasis to be threatened. In this symposium, recent advances in neurological response to energy and social stress, from energy to social homeostasis, will be presented.
| Speaker | Affiliation | Title |
|---|---|---|
| Hyun Woo Lee | Korea University | Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice |
| Hyosang Lee | Daegu Gyeongbuk Institute of Science and Technology | Astrocytes in the lateral septum respond to aversive stimuli and regulate stress responses |
| Sora Shin | Virginia Tech | Thalamic-hippocampal interplay in early life stress-induced dual-harm |
| Kazuhiro Nakamura | Nagoya University | Central neural network to defend life from environmental stresses |
Jung Eun Shin (Dong-A University)
Hwan Tae Park (Dong-A University)
ModeratorHwan Tae Park (Dong-A University)
The nervous system is particularly vulnerable to various insults due to the peculiar cytoarchitecture of neurons and glia constructing neural networks. Neural tissue can be damaged by mechanical injury, neurotoxins and disease conditions. How neural cells respond to these insults determines the degree of recovery after injury. The repair process encompasses axonal maintenance and regeneration as well as interaction between neurons and non-neuronal cells to reshape damaged tissue. In this symposium, leading scientists in the field will discuss the mechanisms underlying axonal regeneration and glial repair with a special focus on the role of different cell types in the neural repair process.
| Speaker | Affiliation | Title |
|---|---|---|
| Young-Jin Son | Temple University | Oligodendrocyte precursor cells prevent sensory nerve regeneration |
| Byung Gon Kim | Ajou University | Perineural myeloid cell activation in axon regeneration |
| Hosung Jung | Yonsei University | Local mRNA translation in long-term axon survival |
| Hyun Kyoung Lee | Baylor College of Medicine | Mechanistic pathways underlying oligodendrocyte development and repair |
Alan Jung Park (Seoul National University)
ModeratorAlan Jung Park (Seoul National University)
The prefrontal cortex is essential in controlling the information flow during various cognitive tasks, but its underlying neural mechanisms are poorly understood. As in most regions involved in higher cognitive functions, the prefrontal cortex communicates dynamically with multiple neural networks, and the hippocampal systems in the medial temporal lobe are its significant partners. Unveiling the neural mechanisms underlying the seemingly intricate functions of the prefrontal cortex and hippocampal systems (including their interactions) will advance our understanding of how the brain carries out complex cognitive functions. The current symposium will examine the prefrontal cortical and hippocampal functions from various perspectives at different levels (from neural circuits to systems) to provide insights into the neural underpinnings of our higher-level cognition.
| Speaker | Affiliation | Title |
|---|---|---|
| Inah Lee | Seoul National University | The differential firing of the prelimbic and infralimbic cortical neurons in the medial prefrontal cortex in a hippocampal-dependent working memory task |
| Alan Jung Park | Seoul National University | Ventral tegmental-hippocampal-prefrontal circuitry supports cognitive flexibility |
| Suk-ho Lee | Seoul National University | Prefrontal Mitochondria-dependent short-term plasticity regulates extinction of trace fear memory |
| Yuji Naya | Peking University | Different functional roles of hippocampus and prefrontal cortex in representing the cognitive map when remembering an egocentric target location |
Sang Ah Lee (Seoul National University)
ModeratorSang Ah Lee (Seoul National University)
Human brain development is a protracted process, with its final stages extending into the early twenties. The maturation of frontal-subcortical networks peaks during adolescence and plays a crucial role in the emergence of higher-order cognitive abilities. This symposium brings together experts in the field of human neuroscience to share their research on brain and cognitive development in adolescence. We will discuss topics such as episodic memory, meta-cognition, social cognition, and value-based decision-making, with the aim to provide an overview of the latest research directions on the neurodevelopmental origins of higher-order cognition in adolescence. We believe that this symposium will interest researchers from various areas of neuroscience and attract new attendees to the KSBNS.
| Speaker | Affiliation | Title |
|---|---|---|
| Sang Ah Lee | Seoul National University | The role of the cortico-hippocampal network in adolescent episodic memory |
| Sunhae Sul | Pusan National University | Neurobehavioral underpinnings of social decision making in adolescence |
| Dongil Chung | Ulsan National Institute of Science and Technology | Exploration and exploitation in adolescence during multi-feature reward learning |
| Vinod Menon | Stanford University | Typical and atypical development of social communication systems |
Euitae Kim (Seoul National University)
ModeratorEuitae Kim (Seoul National University)
In this session, the presenters will show how neuroimaging techniques can be applied for researches into mental illnesses like schizophrenia.
Schizophrenia is a chronic, severe mental illness characterized by psychotic symptoms such as hallucinations and delusions, often coupled with cognitive and social impairments. The development of schizophrenia is thought to be related with the alteration of the neurotransmitter system in the brain, including dopamine, GABA, glutamate, and so on. Meanwhile, the alteration is considered to be initiated by neuroinflammation in the early stage of schizophrenia.
The presenters will introduce the neuroimaging techniques and present how they are implemented for the research into neurotransmitter systems in schizophrenia.
| Speaker | Affiliation | Title |
|---|---|---|
| Euitae Kim | Seoul National University | Altered dopamine system in treatment-responsive schizophrenia: Lessons from pharmacoimaging studies |
| Shin-ichiro Nakajima | Keio University | Dopamine and glutamate system dysfunction in treatment-resistant schizophrenia |
| Yoo Sung Song | Seoul National University Bundang Hospital | A novel PET ligand for assessing neuroinflammation in the brain |
| Junhee Lee | Uijeongbu Eulji Medical Center | Altered GABA system in psychotic disorders |
Se-Bum Paik (Korea Advanced Institute of Science and Technology)
Sang Wan Lee (Korea Advanced Institute of Science and Technology)
ModeratorSe-Bum Paik (Korea Advanced Institute of Science and Technology)
Sang Wan Lee (Korea Advanced Institute of Science and Technology)
Despite the rapid progress in recent neuroscience research, a complete understanding of brain functions remains elusive, because we do not have a theory or principle that explains numerous experimental observations. This symposium introduces current researches that take theoretical approaches to find mechanisms underlying intelligent functions observed in humans and human-like machines. Topics cover computational frameworks including abstraction and learning, adaptive behavior, causal reasoning, action planning, and probabilistic models for behavioral optimization. We show that combining computational approaches with experimental data and with simulations using artificial network models provides a more complete understanding of intelligent functions in the brain and may elevate neuroscience research to a new level. We are confident that our symposium will be of great interest to a wide range of researchers working in various fields such as neuroscience, cognitive science, developmental neuroscience, and artificial intelligence, as well as to audiences with a broader interest in KSBNS.
| Speaker | Affiliation | Title |
|---|---|---|
| Aurelio Cortese | Advanced Telecommunications Research Institute International | Confidence, abstractions and reinforcement learning in humans and machines |
| Sang Wan Lee | Korea Advanced Institute of Science and Technology | Harnessing the power of reinforcement learning theory to understand biological reinforcement learning, and vice versa |
| Won Mok Shim | Sungkyunkwan University | Hierarchical action planning in a complex naturalistic environment |
| Se-Bum Paik | Korea Advanced Institute of Science and Technology | Imitation as collective learning for population-level optimization |
Yoon-Seong Kim (Rutgers University)
ModeratorYoon-Seong Kim (Rutgers University)
The impairment of glia and vascular cell types has been broadly implicated in neurodegenerative disorders. Advanced molecular, genetic, and imaging tools with animal models enable us to examine detailed changes in individual cell types in normal and pathological aging such as Alzheimer’s disease. In this symposium, speakers will present changes in 3D vascular networks in normal aging, pathological changes of glial cell types in Alzheimer’s disease, and potential therapeutic approaches based on molecular insight gained from preclinical research.
| Speaker | Affiliation | Title |
|---|---|---|
| Yongsoo Kim | Penn State University | Aging drives cerebrovascular network remodeling and functional changes in the mouse brain |
| Heejung Chun | Yonsei University | Severe reactive astrocytes as the cause of Alzheimer's disease and neurodegeneration |
| Jungsu Kim | Indiana University | Targeting astrocytes and microglia for Alzheimer’s disease |
| Inhee Mook | Seoul National University | Molecular pathogenesis-based therapeutic approaches for Alzheimer’s disease |
